Redefining Radial Closure.

Clinically. Comfortably. Clearly.

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SĀPH™ (Suction Activated Patent Hemostasis) is the first and only radial closure device that works with blood flow, not against it.

Leveraging a proprietary suction mechanism, it achieves hemostasis by gently drawing the artery to a soft external seal—without circumferential or downward compression. SĀPH is designed to help minimize the risk of Radial Artery Occlusion (RAO), reduce post-procedure staff burden, and enhance patient comfort.

Developed by a leading interventional cardiologist, SĀPH emphasizes efficiency and simplicity—supporting smoother procedures, preserving future access, and redefining the standard for pain-free closure.

Why SĀPH matters

When was the last time you had a real conversation about improving radial closure–RAO, comfort, staff time?

There are limitations to the conventional radial compression mechanisms of action.

  • Patient pain (6 out of 10) [1]

  • Time intensive for Cath Lab staff (up to 50 minutes) [2]

  • Radial artery occlusion (5% to 10%) [3]

Radial access is now the gold standard.

  • 60% of PCIs in the U.S. use radial (up from 14% in 2011) [4]

  • Chosen for: Safety, speed, and patient comfort

But closure hasn’t kept up.

  • No real innovation in closure devices since radial’s rise

  • Most still rely on circumferential or occlusive compression.

Until now.

SĀPH is designed to streamline radial closure and reduce staff burden.

Precise Alignment

SĀPH features a notch-guided design to support accurate positioning over the access site — helping clinicians align closure with confidence.

Targeted Closure Support

SĀPH is a completely topical system — nothing subdermal. Its integrated keel element supports precise apposition at the arteriotomy site, enabling effortless closure without introducing material beneath the skin.

Predictable Deployment

A simplified design with intuitive visual markers allows consistent setup and reproducibility across a range of experience levels.

Efficient Hemostasis

SĀPH utilizes a proprietary suction-based mechanism to gently approximate the arteriotomy up against the subdermal tissue —promoting effective seal formation without circumferential compression and blocking flow.

Streamlined Workflow

SĀPH reduces complexity at the bedside: no manual pressure, no incremental adjustments, and fewer post-procedure checks. Clinicians know when they’re done — and can move on with confidence.

Evidence at a Glance

  • Device directly addresses RAO by maintaining flow during closure.

    Rashid et al., 2016 (JAHA) – Meta-analysis of RAO

  • Reproducibly delivers patent hemostasis in a simple, consistent way.

    Pancholy et al., 2012 – PROPHET Trial

  • First device purpose-built for consistent patent hemostasis.

    SCAI/ACC/AHA 2021 Guideline Update

  • Proof of concept that suction-based, flow-preserving closure works in humans.

    First-in-Human Feasibility Study (Internal Data, 2025)

  • Will demonstrate head-to-head benefits in real-world patients.

    FUTURE - Brazil 50-Patient Clinical Study (Ongoing, 2025)

“The current hemo static therapies take time and create repetitive tasks from the nursing staff to remove the air. I see that the air removal protocols cannot realistically be followed.

Also, radial artery occlusion is a growing issue. Patients are coming in, sometimes at a young age and your typical CAD patient is going to require multiple caths throughout their lifetime, we hate to lose an access site.”

Bailey Estes

AGNP-C, MSN; Cardiac Cath Lab Scrub Nurse and Researcher; Co-Chair of the ACC Cardiovascular Team Communications Work Group; Cath Lab Digest Editorial Board Greater Abilene Area

About us

Transradial Technologies, Inc. is a medical device company focused on developing a novel, minimally invasive transradial vascular closure device.

Transradial Technologies, Inc. has worldwide and exclusive rights to the technology via an agreement with Transradial Holdings, Inc.

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1. PubMed J Invasive Cardiol. 2021 Feb;33(2):E84-E90. Epub 2021 Jan 21. 2. Berger PB. Cath Lab Digest/CIToday. Sept/Oct 2011 3. Avdikos G, et al. Cardiovasc Diagn Ther. 2017;7(3):305-316. doi:10.21037/cdt.2017.03.14 4. Moussa ID et al. J Am Coll Cardiol. 2013;61(8):812–817. doi:10.1016/j.jacc.2012.11.050 5. PubMed Central 2016 Aug 3;3(2):e000397. doi: 10.1136/openhrt-2015-000397